Clinical and laboratory markers of early diagnosis of diabetic polyneuropathy

Objective. To study the content of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor type B kinase (TrkB) in patients at an early stage diabetic polyneuropathy. Late diagnosis polyneuropathy (DPN) is largely due to presence a subclinical stage, which damage nervous system develops absence complaints from patient.
 Materials methods. 64 with 2 diabetes mellitus 11 persons control group were examined assessment pain status degree peripheral neuropathy using PainDetect, TSS, NSS, NDS scales. Disturbance nerve conduction along nerves lower extremities was studied electroneuromyography (ENMG). The quantitative BDNF TrkB serum carried out enzyme immunoassay.
 Results. increased concentrations (p = 0.001) 0.007) found development clinically evident DPN as compared without DPN. In DPN, there established statistically significant increase expression (2.97 [2.44; 3.37] ng/ml comparison values both 0.022) 0.017). mean level this 4.29 [3.48; 5.62] ng/ml, that also higher than corresponding for 0.032) 0.025). correlates duration (R 0.524; p 0.02), intensity neuropathic 0.402; 0.001), axonal according ENMG data -0.242; 0.03). Correlations between severity course 0.482; 0.01), 0.383; impaired 0.359; 0.003) found.
 Conclusions. elevated occur initial fibers correlate compensation carbohydrate metabolism, neural disorders. obtained allow us consider levels markers